Thermodynamic data are essential for the design and optimization of chemical engineering processes. Typically, the chemical industry is relying on experimental investigations along with empirical equations of state to generate and utilize such data. This approach is expensive, time-consuming and in the case of hazardous substances difficult to conduct. Molecular modeling and simulation is an attractive alternative method to generate such data, which is typically only used by experts because of the lack of versatile and easy-to-use tools. In this work, an efficient simulation tool for the determination of all time-independent thermodynamic properties during a single molecular simulation run is described and applied to various problems, including the systematic assessment of complex thermodynamic properties, the creation of hybrid empirical equations of state and the fully automatized parameterization based on molecular simulation data for real fluids.