In the present work, mono- and binuclear copper complexes with polyfunctional guanidines or carboxylates were synthesized and characterized. The resulting complexes should exhibit structural similarities to the different copper binding sites of the prion protein, in which copper ions are coordinated by various donor sets with nitrogen, oxygen and sulphur functions. To reconstruct the diverse coordination patterns of the protein, guanidines and bisguanidines with additional carbonyl, pyrimidine or thioether groups already known in the working group were first reacted with various copper salts. In addition, three new bisguanidine ligands with N2S2 donor sets and a carboxylate ligand have been synthesized and characterized by various spectroscopic methods.By reaction with polyfunctional guanidines six new copper complexes were prepared and characterized by X-ray crystal structure analysis. The monoguanidine derivatives reacted with various Cu(I) and Cu(II) salts to mono- and dinuclear complexes and a polymeric chain structure with different coordination patterns. The reactions of bisguanidines with N2S2 donor sets led to a neutral, dinuclear complex, as well as complex cations with various counter-ions. The reaction of the carboxylate ligand with CuCl2 gave a dimeric copper complex with a paddlewheel-like cage structure which shows in spite of the sterically more demanding ligand great structural similarities with acetate derivatives such as [Cu2(O2CCH3)4(H2O)2] or [Cr2(O2CCH3)4(H2O)2].The characterization by X-ray crystal structure analysis was completed by other spectroscopic and electrochemical techniques.