In the present study a variable one-pot-two-step method for the modification of hydroxyl groups containing binders with ethoxysilanes was developed in order to produce moisture-curing solvent borne hybrid polymer coatings. Additionally, the structure-property relationships between the mechanical properties and chemical resistance of the cured coatings were investigated. Many properties (hardness, modulus, chemical resistance, gloss) are dominated by the organic backbone of the modified compounds. Coatings based on binders of higher molecular weight and lower functionalities are softer, smoother and less resistant as highly functionalized, low molecular weight alcohols. Nevertheless, the effect of the inorganic compound is obvious. By the addition of aluminum-, boron-, titanium- and zirkonium butylate the hardness of the hybrid polymer coatings is significantly increased. TEOS, although added in larger amounts, is not incorporated into the coatings without adding butylates. Furthermore the addition of TEOS shows no significant effect on most properties, although the barrier effect against water increases with a higher inorganic content. The investigations underline the effect of titanium butylate as a nucleation agent. Adhesion force measurements (AFM) allow the detection of size and structure of the different domains. With this method we were able to find a correlation between the inorganic additives and the structure of the domains. The structures found are in agreement with DMA investigations where the damping shows a strong dependence on the titanium concentration (similar to the Payne effect). Based on this information, a correlation between domain size, shape as well as distribution and relaxation processes can be observed.