The main scope of this thesis is in-situ investigation of reaction mechanism atthe liquid/solid interfaces, where self-organization of adsorbed species takes place,by means of Quartz Crystal Microbalance (QCM).Polyelectrolyte covered TiO2 nanocontainers (NCs) were adsorbed on functionalthiol self-assembled monolayers on a quartz crystal gold electrode. Colloids self-location was strongly inuenced by surface chemistry of particles and substrates as well as bulk conditions like pH and ionic strength. Electric Double Layer and Vander Waals interactions within the system are fundamental for NCs implementation into polymer coatings with perspective self-healing and anti-corrosion properties.The results were in agreement with DLVO theory.Moreover, a new phenomenon of positive frequency shift was observed along adsorption of those particles. It could be explained by formation of a coupled resonator between NCs and a quartz crystal. Thus, QCM probed the contact strength, rather than the particle mass.Furthermore, QCM was employed to examine self-assembly of alkylphosphonicacids on nanorod and continuous nanocrystalline ZnO lons. Proper functionalization is crucial for their performance and selectivity as biosensors and adhesion promoters on engineering metals. It is believed that phosphonic acid partially dissolves ZnO crystals. Released metal ions appeared to form complexes with organic molecules and cover substrate with adsorbate layer. The interfacial processes could be controlled via addition of metal ions into bulk solution, variation of molecules alkyl chain length as well as solvent polarity.QCM data were veried by means of FT-IR spectroscopy, FE-SE microscopy and static water contact angle (WCA) measurements of quartz crystal electrode surfacesafter in-situ experiments.Overall results gave a deep insight into interfacial phenomena delivering requirements for the best performance on the used materials.