TY  - JOUR
AB  - A previous follow-up of the GINIplus study showed that breastfeeding could protectagainst early eczema. However, effects diminished in adolescence, possibly indicating a “reboundeffect” in breastfed children after initial protection. We evaluated the role of early eczema until threeyears of age on allergies until young adulthood and assessed whether early eczema modifies the associationbetween breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) wereconsidered. Information on atopic eczema, asthma, and rhinitis was based on reported physiciansdiagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations.Early eczema was associated with eczema (aORs = 3.2-14.4), asthma (aORs = 2.2-2.7), and rhinitis(aORs = 1.2-2.7) until young adulthood. For eczema, this association decreased with age (p-forinteraction= 0.002-0.006). Longitudinal models did not show associations between breastfeeding andthe respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modifythe association between milk feeding and allergies except for rhinitis in participants without familyhistory of atopy. Early eczema strongly predicts allergies until young adulthood. While preventiveeffects of full breastfeeding on eczema in infants with family history of atopy does not persist untilyoung adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed.
AU  - Libuda, Lars
AU  - Filipiak-Pittroff, Birgit
AU  - Standl, Marie
AU  - Schikowski, Tamara
AU  - Berg, Andrea von
AU  - Heinrich, Joachim
AU  - Berdel, Dietrich
AU  - Gappa, Monika
AU  - Koletzko, Sibylle
AU  - Bauer, Carl-Peter
DA  - 2023
DO  - 10.17619/UNIPB/1-1790
PB  - Universitätsbibliothek
DP  - Universität Paderborn
LA  - eng
IS  - 2780
M2  - 1
PY  - 2023
SN  - 2072-6643
SP  - 1-15
T2  - nutrients
TI  - Full breastfeeding and allergic diseaseslong-term protection or rebound effects?: Lars Libuda, Birgit Filipiak-Pittroff , Marie Standl, Tamara Schikowski, Andrea von Berg, Sibylle Koletzko, Carl-Peter Bauer, Joachim Heinrich, Dietrich Berdel and Monika Gappa
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:466:2-45523
Y2  - 2024-10-03T19:56:16
ER  -