Dietary sugar intake: International time trends in intake levels among children and adolescents and aspects of its relevance for subclinical inflammation [...] / by Karen Aimee Della Corte ; 1. Gutachterin: Prof. Dr. Anette E. Buyken, Paderborn University; 2. Gutachterin: Prof. Dr. Sarah Egert, University of Hohenheim. Paderborn, 2021
Inhalt
ACKNOWLEDGEMENTS
PUBLICATIONS
ZUSAMMENFASSUNG
Table of Contents
LIST OF FIGURES
LIST OF TABLES
ABBREVIATIONS
1 INTRODUCTION
2 THEORETICAL BACKGROUND
2.1 Dietary sugar among children and adolescents – Intake trends/levels and implications for health
2.1.1 Definitions of sugar and assessment methods
2.1.2 Recommended levels and trends of sugar intake
2.1.3 Children and adolescent populations
2.1.4 Obesity and chronic disease risk in children and adolescents
2.1.5 Longitudinal and repeat cross-sectional study designs
2.2 The influence of dietary sugar intake on systemic inflammation
2.2.1 Definition, development and prevalence of systemic inflammation
2.2.3 Possible pathophysiological mechanisms
2.2.4 Evidence from interventional and observational studies
2.3 The influence of dietary sugar intake on type 2 diabetes
3 AIMS AND RESEARCH QUESTIONS
4 GENERAL METHODOLOGY
4.1 Systematic literature review and meta-analysis
4.1.1 Methods and definition of systematic search and meta-analysis
4.1.2 Search strategy and terms
4.1.3 Study selection process and inclusion/exclusion criteria
4.1.4 Statistical methods of meta-analysis
4.2 Population and design of the DONALD Study (Study III)
4.3 Analytical study populations
4.4 24-hour urine samples
4.5 Dietary assessment
4.6 Anthropometric measurements
4.7 Medical examination, interview and parental data
4.8 Collection of blood parameters
4.9 Statistical considerations (Study III)
5 STUDIES
5.1 Study I - World Trends in Sugar-Sweetened Beverage and Dietary Sugar Intakes in Children and Adolescents: A Systematic Review
5.2 Study II - Effect of dietary sugar intake on biomarkers of subclinical inflammation: A systematic review and meta-analysis
5.3 Study III - The prospective association of dietary sugar intake in adolescence with type 2 diabetes and inflammatory markers in young adulthood
6. General Discussion
6.1 Additional considerations
6.1.1 Additional considerations (Study I)
6.1.2 Additional considerations (Study II)
6.1.3 Additional considerations (Study III)
6.2 Research Aims
6.2.1 Aim 1: World trends in SSB and dietary sugar
6.2.2 Aim 2: Dietary sugar and inflammation
6.2.3 Aim 3: Dietary sugar and T2D/inflammation
6.3 Public health relevance and practical implications
7. Conclusions and perspectives
8. References
9. Appendix
10. Versicherung